Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 12/20 | 0.66 |
| ▸ | MAPK9 | P45984 | 12/20 | 0.66 |
| ▸ | JUN | P05412 | 10/20 | 0.66 |
| ▸ | CDK2 | P24941 | 10/20 | 0.66 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.66 |
| ▸ | CDK4 | P11802 | 3/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8233238 | 0.81 | MAPK8 (0.63) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL3649842 | 0.77 | MAPK8 (0.67) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL2342670 | 0.73 | HSD17B10 (0.61) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL2348576 | 0.73 | IGF1R (0.47) | CDK2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL3646457 | 0.72 | MAPK8 (0.60) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL3649000 | 0.72 | MAPK8 (0.60) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL13042854 | 0.72 | DYRK1A (0.66) | MAPK9CDK2MAPK10CDK4GSK3B | |
| SCHEMBL13043178 | 0.71 | DYRK1A (0.59) | CDK2CDK4GSK3BDYRK1AEGFR | |
| SCHEMBL6039720 | 0.70 | MAPK8 (0.74) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL6039763 | 0.70 | MAPK8 (0.81) | MAPK8MAPK9JUNCDK2MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |