Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 20/20 | 0.74 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.74 |
| ▸ | CDK2 | P24941 | 4/20 | 0.74 |
| ▸ | JUN | P05412 | 4/20 | 0.74 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | STK16 | O75716 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.49 |
| ▸ | CDK11B | P21127 | 1/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MAPK4 | P31152 | 1/20 | 0.49 |
| ▸ | TTK | P33981 | 1/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6039410 | 0.89 | MAPK8 (0.59) | MAPK8MAPK9CDK2JUNMAPK10 | |
| SCHEMBL6039793 | 0.83 | MAPK8 (0.53) | MAPK8MAPK9CDK2JUNMAPK10 | |
| SCHEMBL6039599 | 0.76 | MAPK8 (0.66) | MAPK8MAPK9CDK2JUNMAPK10 | |
| SCHEMBL14768234 | 0.76 | MAPK8 (0.64) | MAPK8MAPK9MAPK10MKNK1 | |
| SCHEMBL6039443 | 0.75 | MAPK8 (0.59) | MAPK8MAPK9CDK2JUNMAPK10 | |
| SCHEMBL6039567 | 0.75 | MAPK8 (0.59) | MAPK8MAPK9CDK2JUNMAPK10 | |
| SCHEMBL14175751 | 0.74 | MAPK8 (0.67) | MAPK8MAPK9MAPK10CITDAPK3 | |
| SCHEMBL14768284 | 0.74 | MAPK8 (0.67) | MAPK8MAPK9MAPK10CITDAPK3 | |
| SCHEMBL6039673 | 0.74 | MAPK8 (0.57) | MAPK8MAPK9CDK2JUNMAPK10 | |
| SCHEMBL6039300 | 0.73 | MAPK8 (0.58) | MAPK8MAPK9CDK2JUNMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |