Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763981 | 0.80 | SMN1; SMN2 (0.39) | SMN1; SMN2POLBHTTTSHRGAA | |
| SCHEMBL1590532 | 0.73 | SMN1; SMN2 (0.37) | SMN1; SMN2POLBHTTTSHRGAA | |
| SCHEMBL4719759 | 0.72 | SMN1; SMN2 (0.35) | SMN1; SMN2POLBHTTTSHRGAA | |
| SCHEMBL9191624 | 0.71 | — | — | |
| SCHEMBL8506062 | 0.71 | — | — | |
| SCHEMBL4723949 | 0.70 | SMN1; SMN2 (0.32) | SMN1; SMN2POLBHTTTSHRGAA | |
| SCHEMBL4719946 | 0.69 | POLB (0.36) | SMN1; SMN2POLBHTT | |
| SCHEMBL11121629 | 0.67 | SMN1; SMN2 (0.33) | SMN1; SMN2POLB | |
| SCHEMBL4724222 | 0.67 | SMN1; SMN2 (0.37) | SMN1; SMN2POLBHTTTSHRGAA | |
| SCHEMBL4720873 | 0.67 | LMNA (0.37) | SMN1; SMN2POLBHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |