Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MVD | P53602 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2448827 | 1.00 | ACE (0.51) | ACETHRBALOX12KMT2AALDH1A1 | |
| SCHEMBL2448832 | 1.00 | ACE (0.51) | ACETHRBALOX12KMT2AALDH1A1 | |
| SCHEMBL5540025 | 0.93 | ACE (0.46) | ACETHRBALOX12KMT2AALDH1A1 | |
| SCHEMBL6221760 | 0.81 | KDM4E (0.49) | ACEALDH1A1SMN1; SMN2CA2CHRM2 | |
| SCHEMBL6221764 | 0.81 | KDM4E (0.49) | ACEALDH1A1SMN1; SMN2CA2CHRM2 | |
| SCHEMBL9538232 | 0.81 | ALDH1A1 (0.48) | ACEKMT2AALDH1A1 | |
| SCHEMBL6039762 | 0.80 | ACE (0.55) | ACETHRBALOX12KMT2AALDH1A1 | |
| SCHEMBL3183667 | 0.80 | ACE (0.55) | ACETHRBALOX12KMT2AALDH1A1 | |
| SCHEMBL6786426 | 0.80 | ACE (0.55) | ACETHRBALOX12KMT2AALDH1A1 | |
| SCHEMBL3183657 | 0.80 | ACE (0.55) | ACETHRBALOX12KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633345-A1 | COMPOUNDS INHIBITING THE BINDING OF SAP FOR TREATING OSTEOARTHRITIS | Pentraxin Therapeutics Limited (GB) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004108131-A1 | COMPOUNDS INHIBITING THE BINDING OF SAP FOR TREATING OSTEOARTHRITIS | PENTRAXIN THERAPEUTICS LIMITED (GB) | 2004-12-16 | — | — | WO | disclosed |