Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | HTR7 | P34969 | 4/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6039811 | 0.81 | HTR6 (0.56) | HTR6DRD2HTR2AHTR7HTR1A | |
| SCHEMBL29429815 | 0.81 | HTR6 (0.56) | HTR6DRD2HTR2AHTR7HTR1A | |
| SCHEMBL30725479 | 0.80 | CCNC (0.35) | HTR6DRD2HTR2AHTR7HTR1A | |
| SCHEMBL29174726 | 0.80 | CCNC (0.35) | HTR6DRD2HTR2AHTR7HTR1A | |
| SCHEMBL25269190 | 0.78 | HTR6 (0.36) | HTR6DRD2HTR2AHTR7HTR1A | |
| SCHEMBL25594758 | 0.78 | HTR6 (0.47) | HTR6DRD2HTR2AHTR7HTR1A | |
| SCHEMBL29174646 | 0.78 | CCNC (0.49) | HTR6DRD2HTR2AHTR7HTR1A | |
| SCHEMBL30725457 | 0.78 | CCNC (0.49) | HTR6DRD2HTR2AHTR7HTR1A | |
| SCHEMBL30204075 | 0.78 | CCNT1 (0.40) | HTR6DRD2HTR2AHTR1ACYP3A4 | |
| SCHEMBL25594746 | 0.78 | CCNT1 (0.40) | HTR6DRD2HTR2AHTR1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |