Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PPME1 | Q9Y570 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20355098 | 0.82 | HTR6 (0.51) | HTR6CYP3A4HTR2AHTR2CHTR2B | |
| SCHEMBL29560883 | 0.82 | HTR6 (0.51) | HTR6CYP3A4HTR2AHTR2CHTR2B | |
| SCHEMBL21805760 | 0.80 | AKR1C3 (0.49) | HTR6CYP3A4HTR2AHTR2CHTR2B | |
| SCHEMBL17097143 | 0.80 | HTR6 (0.56) | HTR6CYP3A4HTR2AHTR2CHTR2B | |
| SCHEMBL2110801 | 0.80 | HTR6 (0.49) | HTR6CYP3A4HTR2AHTR2CHTR2B | |
| SCHEMBL5350219 | 0.78 | HTR6 (0.64) | HTR6LMNASMN1; SMN2PLK1 | |
| SCHEMBL16698228 | 0.77 | HTR6 (0.43) | HTR6CYP3A4HTR2AHTR2CHTR2B | |
| SCHEMBL6083213 | 0.77 | HTR6 (0.51) | HTR6PPME1 | |
| SCHEMBL1044745 | 0.76 | BRD4 (0.55) | HTR6HTR2APPME1BRD4 | |
| SCHEMBL16697690 | 0.75 | HTR6 (0.46) | HTR6CYP3A4HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |