Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28114713 | 0.91 | MAP3K14 (0.41) | MAP3K14ALDH1A1CRBNCYP19A1IDO1 | |
| SCHEMBL11288 | 0.89 | — | — | |
| SCHEMBL15494454 | 0.89 | — | — | |
| Ammonia Solution, Strong SCHEMBL25176856 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL3986242 | 0.86 | — | — | |
| Phosphine SCHEMBL22345181 | 0.86 | — | — | |
| SCHEMBL31244467 | 0.86 | — | — | |
| SCHEMBL320576 | 0.86 | — | — | |
| Carbimide SCHEMBL4969122 | 0.84 | MAP3K14 (0.43) | MAP3K14ALDH1A1CRBNCYP19A1IDO1 | |
| Bicarbonate SCHEMBL14918 | 0.82 | MAP3K14 (0.44) | MAP3K14ALDH1A1CRBNCYP19A1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2878376-B1 | Particle agglutination in a tip | ORTHO CLINICAL DIAGNOSTICS INC (US) | 2021-04-21 | — | — | EP | disclosed |
| EP-2878376-A2 | Particle agglutination in a tip | Ortho-Clinical Diagnostics Inc (US) | 2015-06-03 | — | — | EP | disclosed |
| EP-2617493-B1 | Particle agglutination in a tip | ORTHO CLINICAL DIAGNOSTICS INC (US) | 2014-12-31 | — | — | EP | disclosed |
| EP-2617493-A2 | Particle agglutination in a tip | Ortho Clinical Diagnostics Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| EP-2257378-B1 | PARTICLE AGGLUTINATION IN A PIPETTE TIP | ORTHO CLINICAL DIAGNOSTICS INC (US) | 2013-07-17 | — | — | EP | disclosed |
| US-8323585-B2 | Use of fluid aspiration/dispensing tip as a microcentrifuge tube | ORTHO-CLINICAL DIAGNOSTICS, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20120276654-A1 | USE OF FLUID ASPIRATION/DISPENSING TIP AS A MICROCENTRIFUGE TUBE | ORTHO-CLINICAL DIAGNOSTICS, INC. (US) | 2012-11-01 | — | — | US | disclosed |
| US-8273297-B2 | Particle agglutination in a tip | ORTHO-CLINICAL DIAGNOSTICS, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-20120040446-A1 | PARTICLE AGGLUTINATION IN A TIP | ORTHO-CLINICAL DIAGNOSTICS, INC. (US) | 2012-02-16 | — | — | US | disclosed |
| US-8048376-B2 | Particle agglutination in a tip | ORTHO-CLINICAL DIAGNOSTICS, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| WO-2009114333-A2 | PARTICLE AGGLUTINATION IN A TIP | ORTHO-CLINICAL DIAGNOSTICS, INC. (US) | 2009-09-17 | — | — | WO | disclosed |
| EP-0934523-A4 | METHOD AND APPARATUS USEFUL FOR DETECTING BLOODGROUP ANTIGENS AND ANTIBODIES | GAMMA BIOLOGICALS INC (US) | 2002-01-23 | — | — | EP | disclosed |
| EP-0934523-A1 | METHOD AND APPARATUS USEFUL FOR DETECTING BLOODGROUP ANTIGENS AND ANTIBODIES | GAMMA BIOLOGICALS, INC. (US) | 1999-08-11 | — | — | EP | disclosed |
| US-5905028-A | SAMPLING ERYTHROCYTES, INCUBATING IN TUBE WITH IMMUNOREACTIVE PARTICLE LAYERS, CENTRIFUGING TO PELLET NONREACTIVE CELLS, CORRELATING ATTACHMENT WITH SEROTYPE | GAMMA BIOLOGICALS, INC. (US) | 1999-05-18 | — | — | US | disclosed |
| WO-1998016831-A1 | METHOD AND APPARATUS USEFUL FOR DETECTING BLOODGROUP ANTIGENS AND ANTIBODIES | GAMMA BIOLOGICALS, INC. (US) | 1998-04-23 | — | — | WO | disclosed |
| WO-1998016832-A1 | METHOD AND APPARATUS USEFUL FOR DETECTING BLOODGROUP ANTIGENS AND ANTIBODIES | GAMMA BIOLOGICALS, INC. (US) | 1998-04-23 | — | — | WO | disclosed |
| US-5665558-A | Method and apparatus useful for detecting bloodgroup antigens and antibodies | GAMMA BIOLOGICALS, INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0760953-A1 | METHOD AND APPARATUS USEFUL FOR DETECTING BLOODGROUP ANTIGENS AND ANTIBODIES | GAMMA BIOLOGICALS, INC. (US) | 1997-03-12 | — | — | EP | disclosed |
| WO-1995031731-A9 | METHOD AND APPARATUS USEFUL FOR DETECTING BLOODGROUP ANTIGENS AND ANTIBODIES | — | 1995-12-28 | — | — | WO | disclosed |
| WO-1995031731-A1 | METHOD AND APPARATUS USEFUL FOR DETECTING BLOODGROUP ANTIGENS AND ANTIBODIES | GAMMA BIOLOGICALS, INC. (US) | 1995-11-23 | — | — | WO | disclosed |