Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.61 |
| ▸ | CCNT1 | O60563 | 12/20 | 0.61 |
| ▸ | CDK9 | P50750 | 12/20 | 0.61 |
| ▸ | CDK7 | P50613 | 11/20 | 0.61 |
| ▸ | CCNH | P51946 | 10/20 | 0.61 |
| ▸ | MNAT1 | P51948 | 9/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.61 |
| ▸ | CCNK | O75909 | 10/20 | 0.51 |
| ▸ | CDK12 | Q9NYV4 | 10/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | JUN | P05412 | 4/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19605646 | 0.83 | CDK7 (0.56) | CDK2CCNT1CDK9CDK7CCNH | |
| SCHEMBL19600360 | 0.82 | CDK7 (0.56) | CDK2CCNT1CDK9CDK7CCNH | |
| SCHEMBL29994336 | 0.82 | CCNT1 (0.59) | CDK2CCNT1CDK9CDK7CCNH | |
| SCHEMBL16655358 | 0.82 | CCNT1 (0.59) | CDK2CCNT1CDK9CDK7CCNH | |
| Hydrochloric Acid SCHEMBL17688367 | 0.82 | CDK7 (0.55) | CDK2CCNT1CDK9CDK7CCNH | |
| SCHEMBL22930831 | 0.80 | EGFR (0.56) | CDK2CCNT1CDK9CDK7CCNH | |
| SCHEMBL19580260 | 0.80 | CDK7 (0.53) | CDK2CCNT1CDK9CDK7CCNH | |
| SCHEMBL19580261 | 0.80 | CDK7 (0.53) | CDK2CCNT1CDK9CDK7CCNH | |
| SCHEMBL6039764 | 0.78 | CDK2 (0.78) | CDK2CCNT1CDK9CDK7CCNH | |
| SCHEMBL29994490 | 0.78 | CDK2 (0.78) | CDK2CCNT1CDK9CDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |