Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.57 |
| ▸ | PNP | P00491 | 1/20 | 0.54 |
| ▸ | NT5E | P21589 | 1/20 | 0.53 |
| ▸ | KRAS | P01116 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.52 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.51 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.51 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.51 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.51 |
| ▸ | ENTPD1 | P49961 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6041237 | 1.00 | TGM2 (0.57) | TGM2PNPNT5EKRASALDH1A1 | |
| SCHEMBL1762981 | 0.99 | TGM2 (0.57) | TGM2PNPNT5EKRASALDH1A1 | |
| SCHEMBL1762987 | 0.99 | TGM2 (0.57) | TGM2PNPNT5EKRASALDH1A1 | |
| SCHEMBL15522523 | 0.93 | PNP (0.58) | TGM2PNPNT5EALDH1A1MAPT | |
| SCHEMBL20277567 | 0.93 | PNP (0.58) | TGM2PNPNT5EALDH1A1MAPT | |
| SCHEMBL2775572 | 0.93 | PNP (0.58) | TGM2PNPNT5EALDH1A1MAPT | |
| SCHEMBL5315091 | 0.90 | TGM2 (0.58) | TGM2PNPNT5EKRASFUT5 | |
| SCHEMBL5315097 | 0.90 | TGM2 (0.58) | TGM2PNPNT5EKRASFUT5 | |
| SCHEMBL17893049 | 0.90 | PNP (0.66) | TGM2PNPNT5EKRASFUT5 | |
| SCHEMBL15794376 | 0.88 | TGM2 (0.59) | TGM2PNPNT5EKRASFUT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060073581-A1 | Crystal structures of bacterial guanylate kinases | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2006-04-06 | — | — | US | disclosed |
| US-20050187718-A1 | Recombinant polypeptide comprising amino acid sequence encoded by polynucleotide that hybridizes under stringent conditions to complementary strand of polynucleotide and having at least one biological activity of guanylate kinase from S. pneumoniae; treatment of pneumonia, meningitis, sinusitis | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2005-08-25 | — | — | US | disclosed |