⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10887893 | 1.00 | ALDH1A1 (0.31) | — | |
| SCHEMBL31441097 | 0.90 | — | — | |
| SCHEMBL6672894 | 0.87 | — | — | |
| SCHEMBL3072220 | 0.86 | — | — | |
| SCHEMBL7712025 | 0.86 | — | — | |
| SCHEMBL11486389 | 0.85 | ALDH1A1 (0.32) | — | |
| SCHEMBL11486387 | 0.85 | — | — | |
| SCHEMBL7741571 | 0.83 | CYP1A2 (0.48) | — | |
| SCHEMBL1553552 | 0.83 | — | — | |
| SCHEMBL7733156 | 0.83 | CYP1A2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105152846-A | Method for efficiently preparing cylopropyl ethylnen | JIUJIANG ZHONGTIAN PHARMACEUTICAL CO LTD | 2015-12-16 | — | — | CN | claimed |
| CN-103044230-B | Preparation method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone | HUNAN CHEMICAL ENGINEERING INST. (CN) | 2014-10-08 | — | — | CN | claimed |
| CN-103044230-A | Preparation method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone | HUNAN RES INST CHEMICAL IND | 2013-04-17 | — | — | CN | claimed |
| US-5288932-A | Halogenation a hydroxymethyl cyclopropane with methane sulfonyl halide in the presence of trialkylamine in one pot, without isolation the mesyl halide | HUELS AKTIENGESELLSCHAFT (DE) | 1994-02-22 | — | — | US | claimed |
| US-20230038470-A1 | DOUBLE METAL CYANIDE CATALYST, PREPARATION METHOD THEREFOR, AND METHOD FOR PREPARING POLYOL | PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) | 2023-02-09 | — | — | US | disclosed |
| CN-109400542-B | Preparation method of cyproconazole | 淮安国瑞化工有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-109535091-B | Method for synthesizing cyproconazole by using 1- (4-chlorphenyl) -2- (1H-1,2, 4-triazole-1-yl) ethanone | 淮安国瑞化工有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-209128342-U | A kind of reaction unit being lower than raw material for product boiling point | 浙江华海天诚药业有限公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-109400542-A | Novel preparation method of cyproconazole | 淮安国瑞化工有限公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-106554345-B | A kind of recycling of phosphorus pentachloride chlorinated secondary product and the method utilized | 杭州杜易科技有限公司 | 2018-11-30 | — | — | CN | disclosed |
| CN-105820128-B | A kind of preparation method of cyproconazole | 江西华士药业有限公司 | 2018-01-19 | — | — | CN | disclosed |
| CN-106554345-A | A kind of recovery of phosphorus pentachloride chlorinated secondary product and the method for utilizing | 杭州杜易科技有限公司 | 2017-04-05 | — | — | CN | disclosed |
| CN-1281840-A | Process for preparation of cyclopropyl acethlene derivative | KURARAY CO (JP) | 2001-01-31 | — | — | CN | disclosed |
| US-6150526-A | Piperidine derivative having renin inhibiting activity | HOFFMANN-LA ROCHE INC. (US) | 2000-11-21 | — | — | US | disclosed |
| US-6051712-A | PREVENTION OF HIGH BLOOD PRESSURE AND CARDIAC INSUFFICIENCY, AS WELL AS GLAUCOMA, CARDIAC INFARCT, KIDNEY INSUFFICIENCY AND RESTENOSIS | HOFFMANN-LA ROCHE INC. (US) | 2000-04-18 | — | — | US | disclosed |
| CN-1202152-A | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 1998-12-16 | — | — | CN | disclosed |
| CN-1191856-A | Process for preparing cyclopropyl acetylene derivatives | KURARAY CO (JP) | 1998-09-02 | — | — | CN | disclosed |
| US-5399544-A | Herbicides | BASF AKTIENGESELLSCHAFT (DE) | 1995-03-21 | — | — | US | disclosed |
| US-4093622-A | Pyridine esters of cyclopropane-carboxylic acid | ZOECON CORPORATION (US) | 1978-06-06 | — | — | US | disclosed |
| US-3995054-A | MITICIDES | ZOECON CORPORATION (US) | 1976-11-30 | — | — | US | disclosed |