Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Enrofloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.89 |
| ▸ | LMNA | P02545 | 3/20 | 0.89 |
| ▸ | HPGD | P15428 | 3/20 | 0.89 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.89 |
| ▸ | MAPT | P10636 | 1/20 | 0.89 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.84 |
| ▸ | TOP2A | P11388 | 1/20 | 0.84 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.84 |
| ▸ | BRD4 | O60885 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.57 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Enrofloxacin SCHEMBL17554684 | 0.94 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL149150 | 0.94 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL29349852 | 0.94 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL6742652 | 0.94 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL17554678 | 0.93 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL16784595 | 0.93 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL10741694 | 0.93 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL8027963 | 0.93 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL29649713 | 0.93 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL9788077 | 0.93 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115586278-A | Detection method for quinolone drug residues in veterinary drug preparation | 石家庄海关技术中心 | 2023-01-10 | — | — | CN | disclosed |
| CN-104198626-B | Trace enrofloxacin extracting and enriching and quantitative method on suspended particulate substance in water | 哈尔滨工业大学 | 2016-06-22 | — | — | CN | disclosed |
| EP-1694302-A1 | TASTE MASKED PHARMACEUTICAL COMPOSITIONS COMPRISING BITTER DRUG AND pH SENSITIVE POLYMER | Council of Scientific and Industrial Research (IN) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005055987-A1 | TASTE MASKED PHARMACEUTICAL COMPOSITIONS COMPRISING BITTER DRUG AND pH SENSITIVE POLYMER | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2005-06-23 | — | — | WO | disclosed |
| US-20050136114-A1 | Taste masked pharmaceutical compositions comprising bitter drug and pH sensitive polymer | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-06-23 | — | — | US | disclosed |
| US-6391336-B1 | SOLID COMPOSITION COMPRISING COMPLEXED ACTIVE AGENT DISPERSED THROUGHOUT SOLID CALCIUM SULFATE DIHYDRATE MATRIX | ROYER BIOMEDICAL, INC. | 2002-05-21 | — | — | US | disclosed |
| EP-0977725-A1 | NEW FATTY ACID DERIVATIVES | NORSK HYDRO ASA (NO) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998032718-A1 | NEW FATTY ACID DERIVATIVES | NORSK HYDRO ASA (NO) | 1998-07-30 | — | — | WO | disclosed |