Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6045312 | 0.98 | PIM1 (0.56) | PIM1KMT2AMEN1TDP1HDAC3 | |
| SCHEMBL6045244 | 0.91 | PIM1 (0.41) | PIM1KMT2AMEN1TDP1HDAC3 | |
| SCHEMBL6045358 | 0.80 | PIM1 (0.43) | PIM1KMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL13305308 | 0.76 | PIM1 (0.65) | PIM1KMT2AMEN1TDP1HDAC3 | |
| SCHEMBL5082472 | 0.76 | CYP2D6 (0.61) | PIM1KMT2AMEN1TDP1USP2 | |
| Hydrochloric Acid SCHEMBL3441267 | 0.75 | CYP2D6 (0.60) | PIM1KMT2AMEN1TDP1USP2 | |
| SCHEMBL23352468 | 0.73 | PIM1 (0.61) | PIM1KMT2AMEN1TDP1HDAC3 | |
| SCHEMBL9419643 | 0.72 | CA1 (0.40) | ALDH1A1CACNA1B | |
| SCHEMBL29444947 | 0.71 | MEN1 (0.71) | PIM1KMT2AMEN1TDP1HDAC3 | |
| SCHEMBL6104044 | 0.70 | PIM1 (0.60) | PIM1KMT2AMEN1TDP1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060241108-A1 | Substituted phenoxazines and acridones as inhibitors of AKT | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2006-10-26 | — | — | US | claimed |
| WO-2006094207-A2 | SUBSTITUTED PHENOXAZINES AND ACRIDONES AS INHIBITORS OF AKT | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2006-09-08 | — | — | WO | claimed |
| US-20060241108-A1 | Substituted phenoxazines and acridones as inhibitors of AKT | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2006-10-26 | — | — | US | disclosed |
| WO-2006094207-A2 | SUBSTITUTED PHENOXAZINES AND ACRIDONES AS INHIBITORS OF AKT | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241108-A1 | Substituted phenoxazines and acridones as inhibitors of AKT | AKT1S1, AKT3, PIK3CA | PIM1 572/4885KMT2A 1181/4885MEN1 4175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.