Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 17/20 | 0.68 |
| ▸ | MMP2 | P08253 | 15/20 | 0.68 |
| ▸ | MMP1 | P03956 | 11/20 | 0.68 |
| ▸ | MMP8 | P22894 | 7/20 | 0.68 |
| ▸ | VIPR2 | P41587 | 1/20 | 0.64 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.60 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6046079 | 1.00 | MMP9 (0.68) | MMP9MMP2MMP1MMP8VIPR2 | |
| SCHEMBL6046070 | 0.88 | MMP9 (0.81) | MMP9MMP2MMP1MMP8ADAMTS4 | |
| SCHEMBL6046063 | 0.88 | MMP9 (0.81) | MMP9MMP2MMP1MMP8ADAMTS4 | |
| SCHEMBL6046057 | 0.81 | MMP9 (1.00) | MMP9MMP2MMP1MMP8ADAMTS4 | |
| SCHEMBL6046048 | 0.81 | MMP9 (1.00) | MMP9MMP2MMP1MMP8ADAMTS4 | |
| SCHEMBL6046094 | 0.81 | MMP9 (1.00) | MMP9MMP2MMP1MMP8ADAMTS4 | |
| SCHEMBL6046088 | 0.81 | MMP9 (1.00) | MMP9MMP2MMP1MMP8ADAMTS4 | |
| SCHEMBL6046178 | 0.81 | MMP9 (0.83) | MMP9MMP2MMP1MMP8ADAMTS4 | |
| SCHEMBL6046129 | 0.81 | MMP9 (0.83) | MMP9MMP2MMP1MMP8ADAMTS4 | |
| SCHEMBL6046121 | 0.81 | MMP9 (0.83) | MMP9MMP2MMP1MMP8ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576664-B1 | 1-amido-2-hydroxy-substituted-indanes; suppressing production of tumor necrosis factor | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-06-10 | — | — | US | claimed |
| US-20060281699-A1 | Methods, compositions and compound assays for inhibiting amyloid-beta protein production | MERCHIERS PASCAL G | 2006-12-14 | — | — | US | disclosed |
| US-6576664-B1 | 1-amido-2-hydroxy-substituted-indanes; suppressing production of tumor necrosis factor | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-06-10 | — | — | US | disclosed |