Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.33 |
| ▸ | TUBB | P07437 | 5/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.33 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.33 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.33 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.33 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9309968 | 0.69 | TSHR (0.43) | AKR1B1TPMTMAPTHPGD | |
| SCHEMBL1866981 | 0.69 | — | — | |
| SCHEMBL290102 | 0.67 | TPMT (0.48) | TPMTHDAC1HDAC6 | |
| SCHEMBL31427488 | 0.67 | PKM (0.34) | AKR1B1 | |
| SCHEMBL298212 | 0.64 | POLB (0.51) | TPMTHTT | |
| SCHEMBL6192702 | 0.63 | CYP3A4 (0.41) | TPMTHDAC1HDAC6MAPTHPGD | |
| SCHEMBL19585743 | 0.63 | KDM4E (0.48) | TPMT | |
| SCHEMBL17831135 | 0.63 | KDM4E (0.48) | TPMTMAPT | |
| SCHEMBL26231300 | 0.62 | NR4A1 (0.50) | MAPTHPGDHTT | |
| SCHEMBL4053749 | 0.62 | TFPI2 (0.35) | TPMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513289-B2 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. (US) | 2013-08-20 | — | — | US | disclosed |
| US-20120040999-A1 | P38 KINASE INHIBITING AGENTS | MERCK SHARP & DOHME LLC | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040999-A1 | P38 KINASE INHIBITING AGENTS | MAPK1, MAPK8, MAPKAPK2 | AKR1B1 822/4885TUBB4A 1201/4885TUBB 556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.