Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.56 |
| ▸ | RET | P07949 | 8/20 | 0.56 |
| ▸ | KIF5B | P33176 | 8/20 | 0.56 |
| ▸ | EGFR | P00533 | 6/20 | 0.56 |
| ▸ | FLT1 | P17948 | 5/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.50 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6046881 | 0.89 | KDR (0.60) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL6046871 | 0.89 | EGFR (0.62) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL5237480 | 0.83 | KDR (0.82) | KDRRETKIF5BEGFRFLT1 | |
| Hydrochloric Acid SCHEMBL8204871 | 0.81 | KDR (0.80) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL13310108 | 0.81 | KDR (0.50) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL3962043 | 0.80 | SRC (0.62) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL535300 | 0.80 | KDR (0.47) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL17179601 | 0.78 | EGFR (0.68) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL14964683 | 0.77 | EGFR (0.80) | KDRRETKIF5BEGFRJAK3 | |
| Hydrochloric Acid SCHEMBL8436 | 0.76 | EGFR (0.68) | KDRRETKIF5BEGFRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633365-A1 | MACROCYCLIC QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004105765-A1 | MACROCYCLIC QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-12-09 | — | — | WO | disclosed |