Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.62 |
| ▸ | KDR | P35968 | 15/20 | 0.60 |
| ▸ | FLT1 | P17948 | 2/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.60 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.60 |
| ▸ | FLT4 | P35916 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.58 |
| ▸ | EGFR | P00533 | 4/20 | 0.54 |
| ▸ | RET | P07949 | 4/20 | 0.54 |
| ▸ | KIF5B | P33176 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL535722 | 0.86 | SRC (0.57) | SRCKDRFLT1FGFR1EPHB2 | |
| SCHEMBL6046871 | 0.84 | EGFR (0.62) | SRCKDRFLT1FGFR1EPHB2 | |
| SCHEMBL5239666 | 0.84 | KDR (0.80) | KDRFLT1FLT4HDAC3HDAC4 | |
| SCHEMBL3958826 | 0.84 | EGFR (0.62) | SRCKDRFLT1FGFR1EPHB2 | |
| SCHEMBL17179601 | 0.81 | EGFR (0.68) | SRCKDRFLT1FGFR1EPHB2 | |
| SCHEMBL6046878 | 0.80 | KDR (0.56) | KDRFLT1FGFR1EPHB2FLT4 | |
| SCHEMBL6046884 | 0.80 | KDR (0.63) | SRCKDRFLT1FGFR1EPHB2 | |
| SCHEMBL13404545 | 0.80 | EGFR (0.54) | SRCKDRFLT1FGFR1EPHB2 | |
| SCHEMBL6664906 | 0.80 | SRC (0.68) | SRCKDRFLT1FGFR1EPHB2 | |
| SCHEMBL3957994 | 0.80 | KDR (0.59) | SRCKDRFLT1FGFR1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2077845-A2 | MACROCYCLIC QUINAZOLINE DERIVATIVES AS VEGFR3 INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008049902-A2 | MACROCYCLIC QUINAZOLINE DERIVATIVES AS VEGFR3 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-05-02 | — | — | WO | disclosed |