Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | F10 | P00742 | 2/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6048512 | 0.98 | SLC6A4 (0.53) | SLC6A4SLC6A2SLC6A3HTR2AF10 | |
| SCHEMBL3464186 | 0.84 | DPP4 (0.54) | SLC6A4SLC6A2GRM2CYP1A2CYP3A4 | |
| SCHEMBL6048524 | 0.84 | CYP1A2 (0.46) | SLC6A4SLC6A2SLC6A3HTR2ACYP1A2 | |
| SCHEMBL6772767 | 0.83 | SLC6A4 (0.53) | SLC6A4SLC6A2SLC6A3HTR2AGRM2 | |
| Hydrochloric Acid SCHEMBL6048562 | 0.82 | DPP4 (0.52) | SLC6A4SLC6A2GRM2CYP1A2CYP3A4 | |
| Bromide SCHEMBL27653706 | 0.82 | DPP4 (0.52) | SLC6A4SLC6A2GRM2CYP1A2CYP3A4 | |
| SCHEMBL24582843 | 0.82 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3GRM2CYP1A2 | |
| Hydrochloric Acid SCHEMBL6048504 | 0.82 | CYP1A2 (0.45) | SLC6A4SLC6A2SLC6A3HTR2ACYP1A2 | |
| SCHEMBL8035321 | 0.81 | SLC6A2 (0.54) | SLC6A4SLC6A2SLC6A3GRM2CYP1A2 | |
| SCHEMBL6048522 | 0.81 | CYP1A2 (0.50) | SLC6A4SLC6A2SLC6A3HTR2AGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202953-B1 | SUBSTITUTED 2-DIALKYLAMINOALKYLBIPHENYL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2006-08-30 | — | — | EP | claimed |
| US-6710080-B2 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2004-03-23 | — | — | US | claimed |
| JP-2003506426-A | — | — | 2003-02-18 | — | — | JP | claimed |
| US-20020198251-A1 | Substituted 2-dialkylaminoalkylbiphenyl derivatives | GRUENENTHAL GMBH (DE) | 2002-12-26 | — | — | US | claimed |
| EP-1202953-A2 | SUBSTITUTED 2-DIALKYLAMINOALKYLBIPHENYL DERIVATIVES | Grünenthal GmbH (DE) | 2002-05-08 | — | — | EP | claimed |
| WO-2001010816-A2 | SUBSTITUTED 2-DIALKYLAMINOALKYLBIPHENYL DERIVATIVES | Grünenthal GmbH (DE) | 2001-02-15 | — | — | WO | claimed |
| EP-1202953-B1 | SUBSTITUTED 2-DIALKYLAMINOALKYLBIPHENYL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2006-08-30 | — | — | EP | disclosed |
| US-6710080-B2 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2004-03-23 | — | — | US | disclosed |
| US-20020198251-A1 | Substituted 2-dialkylaminoalkylbiphenyl derivatives | GRUENENTHAL GMBH (DE) | 2002-12-26 | — | — | US | disclosed |
| EP-1202953-A2 | SUBSTITUTED 2-DIALKYLAMINOALKYLBIPHENYL DERIVATIVES | Grünenthal GmbH (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001010816-A2 | SUBSTITUTED 2-DIALKYLAMINOALKYLBIPHENYL DERIVATIVES | Grünenthal GmbH (DE) | 2001-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020198251-A1 | Substituted 2-dialkylaminoalkylbiphenyl derivatives | LIPA, PKD1, PKD2 | SLC6A4 1586/4885SLC6A2 1499/4885SLC6A3 1456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.