SCHEMBL8035321

SCHEMBL8035321

CN(C)Cc1ccccc1-c1ccc(Br)cc1

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 2/20 0.54
SLC6A4 P31645 2/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
SLC6A3 Q01959 1/20 0.54
CYP1A2 P05177 10/20 0.48
CYP2D6 P10635 9/20 0.48
CYP3A4 P08684 8/20 0.48
ALDH1A1 P00352 5/20 0.48
CLK4 Q9HAZ1 3/20 0.48
CYP2C19 P33261 3/20 0.48
HSD17B10 Q99714 2/20 0.48
BACE1 P56817 1/20 0.46
GRM2 Q14416 1/20 0.45
LMNA P02545 1/20 0.45
KDM4E B2RXH2 2/20 0.43
HPGD P15428 1/20 0.43
TAAR1 Q96RJ0 1/20 0.41
TSHR P16473 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3464186 0.84 DPP4 (0.54) SLC6A2SLC6A4CYP1A2CYP2D6CYP3A4
SCHEMBL6772767 0.83 SLC6A4 (0.53) SLC6A2SLC6A4SLC6A3CYP1A2CYP2D6
Bromide SCHEMBL27653706 0.82 DPP4 (0.52) SLC6A2SLC6A4CYP1A2CYP2D6CYP3A4
Hydrochloric Acid SCHEMBL6048562 0.82 DPP4 (0.52) SLC6A2SLC6A4CYP1A2CYP2D6CYP3A4
SCHEMBL6048522 0.81 CYP1A2 (0.50) SLC6A2SLC6A4SLC6A3CYP1A2CYP2D6
SCHEMBL28102007 0.81 CYP1A2 (0.47) SLC6A2SLC6A4SLC6A3CYP1A2CYP2D6
SCHEMBL3184690 0.81 CYP1A2 (0.47) SLC6A2SLC6A4SLC6A3CYP1A2CYP2D6
SCHEMBL6048563 0.81 SLC6A4 (0.54) SLC6A2SLC6A4SLC6A3CYP1A2CYP2D6
SCHEMBL5094478 0.80 CYP1A2 (0.47) SLC6A2SLC6A4SMN1; SMN2SLC6A3CYP1A2
Hydrochloric Acid SCHEMBL6048561 0.80 CYP1A2 (0.49) SLC6A2SLC6A4SLC6A3CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0636367-B1 Use of phenylalkylamines for producing cholesterol lowering agents HOFFMANN LA ROCHE (CH) 2000-03-29 EP disclosed
US-5637771-A Compound useful for lowering cholesterol HOFFMANN-LA ROCHE INC. (US) 1997-06-10 US disclosed
US-5574071-A ADMINISTERING PHENYLALKYLAMINO KETONES HOFFMANN-LA ROCHE INC. (US) 1996-11-12 US disclosed
US-5495048-A ANTICHOLESTEROL AGENTS HOFFMANN-LA ROCHE INC. (US) 1996-02-27 US disclosed
EP-0636367-A1 Use of phenylalkylamines for producing cholesterol lowering agents F. HOFFMANN-LA ROCHE AG (CH) 1995-02-01 EP disclosed