Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 3/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3838650 | 0.94 | MAPT (0.59) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6049385 | 0.91 | MAPT (0.54) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3842196 | 0.88 | CASR (0.52) | CASRHTR7 | |
| SCHEMBL3842550 | 0.79 | MAPT (0.52) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3838152 | 0.78 | MAPT (0.51) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3864346 | 0.78 | MAPT (0.48) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL23901561 | 0.76 | CYP2C19 (0.64) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3838036 | 0.75 | HTR7 (0.62) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6049722 | 0.71 | MEN1 (0.44) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3842075 | 0.71 | PDE4D (0.48) | MAPTHTTGAAHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641465-A2 | COMBINATIONS OF AN ARYL ANILINE BETA-2 ADRENERGIC RECEPTOR AGONIST AND A CORTICOSTEROID | Theravance, Inc. (US) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005025555-A2 | COMBINATIONS OF AN ARYL ANILINE BETA-2 ADRENERGIC RECEPTOR AGONIST AND A CORTICOSTEROID | THERAVANCE, INC. (US) | 2005-03-24 | — | — | WO | disclosed |