Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | SELE | P16581 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049549 | 0.88 | PARP10 (0.39) | RAF1MAPK14KDM4E | |
| SCHEMBL6049651 | 0.85 | PARP10 (0.39) | — | |
| SCHEMBL3630059 | 0.84 | CYP17A1 (0.39) | RAF1MAPK14 | |
| SCHEMBL3623262 | 0.78 | RAF1 (0.39) | RAF1MAPK13RIPK2KDRMMP13 | |
| SCHEMBL12201799 | 0.75 | RAF1 (0.44) | RAF1MAPK13RIPK2KDRMAPK14 | |
| SCHEMBL3629208 | 0.74 | RAF1 (0.43) | RAF1MAPK13RIPK2MMP13MAPK14 | |
| SCHEMBL7810441 | 0.73 | MAPK13 (0.54) | RAF1MAPK13MAPK14 | |
| SCHEMBL13388168 | 0.72 | RAF1 (0.43) | RAF1MAPK13RIPK2ICAM1SELE | |
| SCHEMBL667633 | 0.71 | RAF1 (0.62) | RAF1MAPK13RIPK2KDRMAPK14 | |
| SCHEMBL3630527 | 0.69 | RAF1 (0.43) | RAF1MAPK13RIPK2MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041982-A4 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER PHARMACEUTICALS CORP (US) | 2006-06-14 | — | — | EP | disclosed |
| EP-1041982-A1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | Bayer Corporation (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032111-A1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER CORPORATION (US) | 1999-07-01 | — | — | WO | disclosed |