Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 9/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL667633 | 0.84 | RAF1 (0.62) | RAF1RIPK2MAPK13MAPK14KDR | |
| SCHEMBL3182360 | 0.76 | GALR3 (0.55) | RAF1POLBMAPTMAPK13MAPK14 | |
| SCHEMBL6049567 | 0.75 | RAF1 (0.38) | RAF1RIPK2MAPK13KDM4EMAPK14 | |
| SCHEMBL3182922 | 0.73 | KDR (0.70) | RAF1POLBMAPTMAPK13MAPK14 | |
| SCHEMBL3176365 | 0.73 | RAB9A (0.55) | RAF1POLBMAPTMAPK13NPY5R | |
| SCHEMBL668554 | 0.72 | RPS6KB1 (0.56) | RAF1MAPTRIPK2MAPK13KDM4E | |
| SCHEMBL667909 | 0.72 | RAF1 (0.52) | RAF1POLBMAPTRIPK2MAPK13 | |
| SCHEMBL667893 | 0.72 | RAF1 (0.57) | RAF1POLBMAPTKDM4EMAPK14 | |
| SCHEMBL668206 | 0.72 | RAF1 (0.57) | RAF1MAPK13MAPK14NPY5R | |
| SCHEMBL3182747 | 0.71 | NPY5R (0.49) | RAF1POLBMAPTMAPK13NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041982-B1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER HEALTHCARE LLC (US) | 2011-10-19 | — | — | EP | disclosed |