Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.84 |
| ▸ | CCNA2 | P20248 | 18/20 | 0.84 |
| ▸ | CCNA1 | P78396 | 13/20 | 0.84 |
| ▸ | AURKA | O14965 | 11/20 | 0.84 |
| ▸ | PLK1 | P53350 | 7/20 | 0.84 |
| ▸ | CDK4 | P11802 | 8/20 | 0.71 |
| ▸ | CCND3 | P30281 | 8/20 | 0.71 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.71 |
| ▸ | TTK | P33981 | 2/20 | 0.71 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.71 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4154945 | 0.92 | CDK2 (1.00) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL4158641 | 0.91 | CCNA2 (0.85) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL23855770 | 0.89 | CDK2 (0.84) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL4157095 | 0.86 | CDK2 (0.84) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL4169086 | 0.82 | CDK2 (0.85) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL4152035 | 0.82 | CDK2 (1.00) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL4171065 | 0.82 | CDK2 (1.00) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL15377682 | 0.82 | TTK (0.85) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL4151140 | 0.82 | CCNA2 (0.83) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL6053129 | 0.81 | CCNA2 (0.70) | CDK2CCNA2CCNA1AURKAPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636236-B1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | disclosed |
| EP-1636236-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004104007-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2004-12-02 | — | — | WO | disclosed |