Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 19/20 | 0.70 |
| ▸ | CDK2 | P24941 | 19/20 | 0.70 |
| ▸ | CCNA1 | P78396 | 12/20 | 0.70 |
| ▸ | PLK1 | P53350 | 9/20 | 0.70 |
| ▸ | AURKA | O14965 | 8/20 | 0.70 |
| ▸ | CDK4 | P11802 | 10/20 | 0.60 |
| ▸ | CCND3 | P30281 | 10/20 | 0.60 |
| ▸ | CDK6 | Q00534 | 9/20 | 0.60 |
| ▸ | TTK | P33981 | 2/20 | 0.60 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.60 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4171275 | 0.91 | CCNA2 (0.69) | CCNA2CDK2CCNA1PLK1AURKA | |
| SCHEMBL4167225 | 0.88 | CCNA2 (0.73) | CCNA2CDK2CCNA1PLK1AURKA | |
| SCHEMBL4154945 | 0.83 | CDK2 (1.00) | CCNA2CDK2CCNA1PLK1AURKA | |
| SCHEMBL6052853 | 0.81 | CDK2 (0.84) | CCNA2CDK2CCNA1PLK1AURKA | |
| SCHEMBL23855770 | 0.80 | CDK2 (0.84) | CCNA2CDK2CCNA1PLK1AURKA | |
| SCHEMBL1894768 | 0.79 | PLK1 (0.84) | CCNA2CDK2CCNA1PLK1AURKA | |
| SCHEMBL6053077 | 0.77 | CDK2 (0.68) | CCNA2CDK2CCNA1PLK1AURKA | |
| SCHEMBL6052980 | 0.76 | CCNA2 (0.83) | CCNA2CDK2CCNA1PLK1AURKA | |
| SCHEMBL4157048 | 0.74 | CCNA2 (0.77) | CCNA2CDK2CCNA1PLK1AURKA | |
| SCHEMBL4152035 | 0.74 | CDK2 (1.00) | CCNA2CDK2CCNA1PLK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636236-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004104007-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2004-12-02 | — | — | WO | disclosed |