Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 15/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.33 |
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6054164 | 0.92 | HDAC4 (0.37) | CASP1IL1BCTSK | |
| SCHEMBL5669625 | 0.92 | CASP1 (0.39) | CASP1CASP3CASP6CASP8 | |
| SCHEMBL6054175 | 0.87 | CASP1 (0.38) | CASP1CASP3IL1BCTSLCTSB | |
| SCHEMBL6054163 | 0.87 | CASP1 (0.38) | CASP1CASP3IL1BCTSLCTSB | |
| SCHEMBL6054155 | 0.87 | PTGS1 (0.32) | CASP1CASP3IL1B | |
| SCHEMBL6054149 | 0.86 | CASP1 (0.39) | CASP1CASP3CASP6CASP8IL1B | |
| SCHEMBL6054185 | 0.86 | CASP1 (0.45) | CASP1CASP3 | |
| SCHEMBL6054158 | 0.85 | CASP1 (0.39) | CASP1CASP3IL1BCTSLCTSB | |
| SCHEMBL1896165 | 0.84 | CASP1 (0.38) | CASP1CASP3CASP6CASP8 | |
| SCHEMBL6054181 | 0.82 | CASP1 (0.37) | CASP1IL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053056-B2 | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases | IDUN PHARMACEUTICALS, INC. (US) | 2006-05-30 | — | — | US | claimed |