Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 8/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6054540 | 0.81 | DAO (0.54) | EPHX1HPNMAPTALOX15SIRT5 | |
| SCHEMBL8496233 | 0.76 | MAPT (0.55) | HPNMAPTALOX15SIRT5DAO | |
| SCHEMBL5367845 | 0.75 | EPHX1 (0.46) | CETPEPHX1CHRM2CHRM1CHRM3 | |
| SCHEMBL9417690 | 0.74 | DAO (0.43) | EPHX1HPNMAPTALOX15SIRT5 | |
| SCHEMBL5526402 | 0.73 | CHRM2 (0.50) | CETPEPHX1CHRM2CHRM1CHRM3 | |
| SCHEMBL6054593 | 0.73 | PTGS1 (0.50) | HPNMAPTALOX15SIRT5DAO | |
| SCHEMBL8698399 | 0.71 | PTGS1 (0.49) | HPNMAPTALOX15SIRT5DAO | |
| SCHEMBL5526398 | 0.70 | EPHX1 (0.48) | CETPEPHX1CHRM2CHRM1CHRM3 | |
| SCHEMBL8767800 | 0.70 | PPARA (0.52) | MAPT | |
| SCHEMBL6054536 | 0.70 | MAPT (0.51) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137948-B1 | METHODS AND COMPOSITIONS TO LOWER PLASMA CHOLESTEROL LEVELS | ATHEROGENICS INC (US) | 2006-05-10 | — | — | EP | disclosed |