Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5323671 | 0.97 | — | — | |
| SCHEMBL642696 | 0.93 | — | — | |
| SCHEMBL8200673 | 0.90 | HIF1A (0.43) | HIF1AMAPTPDE4AKDR | |
| SCHEMBL5979256 | 0.90 | HIF1A (0.43) | HIF1AMAPTPDE4AKDR | |
| Water SCHEMBL6572613 | 0.90 | — | — | |
| SCHEMBL2225649 | 0.90 | HIF1A (0.43) | HIF1AMAPTPDE4AKDR | |
| Hydrochloric Acid SCHEMBL1983463 | 0.90 | — | — | |
| Iodide SCHEMBL4299812 | 0.90 | — | — | |
| Hydrochloric Acid SCHEMBL2447319 | 0.87 | HIF1A (0.31) | HIF1AMAPTPDE4AKDR | |
| Hydrochloric Acid SCHEMBL9937376 | 0.87 | HIF1A (0.31) | HIF1AMAPTPDE4AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465740-A4 | REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES | SURMODICS INC (US) | 2006-06-07 | — | — | EP | claimed |
| JP-2005514192-A | — | — | 2005-05-19 | — | — | JP | claimed |
| EP-1465740-A1 | REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES | SurModics, Inc. (US) | 2004-10-13 | — | — | EP | claimed |
| WO-2003055611-A1 | REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES | SURMODICS, INC. (US) | 2003-07-10 | — | — | WO | claimed |
| WO-2000044334-A2 | NOVEL INJECTABLE MUSCLE RELAXANT FORMULATIONS | PATEL DINESH SHANTILAL (IN) | 2000-08-03 | — | — | WO | claimed |
| WO-2000044334-A2 | NOVEL INJECTABLE MUSCLE RELAXANT FORMULATIONS | PATEL DINESH SHANTILAL (IN) | 2000-08-03 | — | — | WO | disclosed |