Water

Water

SCHEMBL6572613

C[N+]1(C)CCNCC1.[OH-]

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL642696 0.96
Bromide SCHEMBL5323671 0.93
SCHEMBL8200673 0.93 HIF1A (0.43)
SCHEMBL2225649 0.93 HIF1A (0.43)
SCHEMBL5979256 0.93 HIF1A (0.43)
Hydrochloric Acid SCHEMBL1983463 0.93
Iodide SCHEMBL4299812 0.93
Hydrochloric Acid SCHEMBL9937376 0.90 HIF1A (0.31)
Hydrochloric Acid SCHEMBL2447319 0.90 HIF1A (0.31)
Bromide SCHEMBL6055853 0.90 HIF1A (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113912079-A CHA molecular sieve synthesis method with high framework adjacent pairing Al content and application 中触媒新材料股份有限公司 2022-01-11 CN disclosed
EP-1406602-A2 USE OF SULFONYL ARYL OR HETEROARYL HYDROXAMIC ACIDS AND DERIVATIVES THEREOF AS AGGRECANASE INHIBITORS Pharmacia Corporation (US) 2004-04-14 EP disclosed
WO-2003007930-A2 USE OF SULFONYL ARYL OR HETEROARYL HYDROXAMIC ACIDS AND DERIVATIVES THEREOF AS AGGRECANASE INHIBITORS PHARMACIA CORPORATION (US) 2003-01-30 WO disclosed
EP-1230219-A1 AROMATIC SULFONS HYDROXAMIC ACID METALLOPROTEASE INHIBITOR G.D. Searle &amp; Co. (US) 2002-08-14 EP disclosed
EP-1183239-A1 AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR G.D. SEARLE &amp; CO. (US) 2002-03-06 EP disclosed
EP-1177173-A1 HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS G.D. SEARLE & CO. (US) 2002-02-06 EP disclosed
WO-2002003994-A1 N SULFONYL AMINOACID DERIVATIVES AS INHIBITORS OF METALLOPROTEINASE G.D. SEARLE & CO. (US) 2002-01-17 WO disclosed
WO-2001085680-A2 SULFONYL ARYL OR HETEROARYL HYDROXAMIC ACID COMPOUNDS PHARMACIA CORPORATION (US) 2001-11-15 WO disclosed
US-20010020021-A1 SULFONYL DIVALENT ARYL OR HETEROARYL HYDROXAMIC ACID COMPOUNDS G.D. SEARLE & CO. 2001-09-06 US disclosed
EP-0973392-A4 SULFONYL DIVALENT ARYL OR HETEROARYL HYDROXAMIC ACID COMPOUNDS MONSANTO CO (US) 2001-05-02 EP disclosed
EP-0983258-A1 N-HYDROXY 4-SULFONYL BUTANAMIDE COMPOUNDS MONSANTO COMPANY (US) 2000-03-08 EP disclosed
EP-0983267-A1 AMIDOAROMATIC RING SULFONAMIDE HYDROXAMIC ACID COMPOUNDS MONSANTO COMPANY (US) 2000-03-08 EP disclosed
EP-0977745-A1 THIOARYL SULFONAMIDE HYDROXAMIC ACID COMPOUNDS MONSANTO COMPANY (US) 2000-02-09 EP disclosed
EP-0973392-A1 SULFONYL DIVALENT ARYL OR HETEROARYL HYDROXAMIC ACID COMPOUNDS MONSANTO COMPANY (US) 2000-01-26 EP disclosed
WO-1999025687-A1 AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR G.D. SEARLE & CO. (US) 1999-05-27 WO disclosed
WO-1998039316-A1 N-HYDROXY 4-SULFONYL BUTANAMIDE COMPOUNDS MONSANTO COMPANY (US) 1998-09-11 WO disclosed
WO-1998038859-A1 SULFONYL DIVALENT ARYL OR HETEROARYL HYDROXAMIC ACID COMPOUNDS MONSANTO COMPANY (US) 1998-09-11 WO disclosed
WO-1998039313-A1 THIOARYL SULFONAMIDE HYDROXAMIC ACID COMPOUNDS MONSANTO COMPANY (US) 1998-09-11 WO disclosed
WO-1998039329-A1 AMIDOAROMATIC RING SULFONAMIDE HYDROXAMIC ACID COMPOUNDS MONSANTO COMPANY (US) 1998-09-11 WO disclosed
US-4127497-A Michael adducts of (substituted) cyclopentadiene and esters: a process therefor and derivatives thereof THE DOW CHEMICAL COMPANY (US) 1978-11-28 US disclosed