Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.40 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17317732 | 0.89 | KDM4E (0.42) | KDM4EL3MBTL1KMT2ARAB9AGRM2 | |
| SCHEMBL6056250 | 0.85 | MEN1 (0.44) | HTTL3MBTL1KMT2ARAB9ATDP1 | |
| SCHEMBL21245509 | 0.84 | PPARG (0.43) | KDM4EHTTKMT2AMEN1ALDH1A1 | |
| SCHEMBL6056303 | 0.83 | PPARG (0.44) | HTTL3MBTL1RAB9ATDP1ALDH1A1 | |
| SCHEMBL6056484 | 0.82 | MAPK1 (0.43) | KDM4EHTTTDP1PPARAGAA | |
| SCHEMBL1913765 | 0.78 | KDM4E (0.45) | KDM4EHTTL3MBTL1KMT2AGRM2 | |
| SCHEMBL3119985 | 0.78 | KDM4E (0.45) | KDM4EHTTL3MBTL1KMT2AGRM2 | |
| SCHEMBL6453186 | 0.78 | KDM4E (0.45) | KDM4EHTTL3MBTL1KMT2AGRM2 | |
| SCHEMBL6056262 | 0.78 | PPARG (0.41) | KMT2AMEN1ALDH1A1SLC1A5PPARG | |
| SCHEMBL7171924 | 0.78 | KDM4E (0.51) | KDM4EHTTL3MBTL1KMT2AGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675582-A1 | COMBINATION COMPRISING AN ALPHA-2-DELTA LIGAND AND AN SSRI AND/OR SNRI FOR TREATMENT OF DEPRESSION AND ANXIETY DISORDERS | Warner-Lambert Company LLC (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005025563-A1 | COMBINATION COMPRISING AN ALPHA-2-DELTA LIGAND AND AN SSRI AND/OR SNRI FOR TREATMENT OF DEPRESSION AND ANXIETY DISORDERS | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-24 | — | — | WO | disclosed |