Ethyl Fumarate

Ethyl Fumarate

SCHEMBL60568

CCOC(=O)/C=C\C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 9/20 1.00
MAPT P10636 4/20 0.48
ATM Q13315 1/20 0.48
NPSR1 Q6W5P4 1/20 0.46
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
TSHR P16473 2/20 0.45
TP53 P04637 1/20 0.45
EGLN1 Q9GZT9 1/20 0.45
EGLN3 Q9H6Z9 1/20 0.45
LMNA P02545 2/20 0.44
MDM2 Q00987 2/20 0.44
MDM4 O15151 1/20 0.44
ALDH1A1 P00352 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethyl Fumarate SCHEMBL30986728 1.00 HCAR2 (1.00) HCAR2MAPTATMNPSR1CA12
Ethyl Fumarate SCHEMBL1133862 1.00 HCAR2 (1.00) HCAR2MAPTATMNPSR1CA12
Ethyl Fumarate SCHEMBL1133858 1.00 HCAR2 (1.00) HCAR2MAPTATMNPSR1CA12
Diethyl Maleate SCHEMBL19873394 1.00 HCAR2 (1.00) HCAR2MAPTATMNPSR1CA12
Diethyl Maleate SCHEMBL9193839 1.00 HCAR2 (1.00) HCAR2MAPTATMNPSR1CA12
Diethyl Maleate SCHEMBL10994275 1.00 HCAR2 (1.00) HCAR2MAPTATMNPSR1CA12
Diethyl Maleate SCHEMBL10994278 1.00 HCAR2 (1.00) HCAR2MAPTATMNPSR1CA12
Ethyl Fumarate SCHEMBL17667143 1.00 HCAR2 (1.00) HCAR2MAPTATMNPSR1CA12
Ethyl Fumarate SCHEMBL60569 1.00 HCAR2 (1.00) HCAR2MAPTATMNPSR1CA12
Diethyl Maleate SCHEMBL28937261 1.00 HCAR2 (1.00) HCAR2MAPTATMNPSR1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 15676 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122095013-A Thick parts and profiles with stone appearance using ionomer resins and bio-fillers 2026-05-26 CN claimed
CN-112803020-B Adhesive with multi-section crosslinking structure and preparation method and application thereof 广州熵能创新材料股份有限公司 2026-05-19 CN claimed
EP-3651248-B1 CURRENT COLLECTOR FOR ELECTRICAL STORAGE DEVICE, METHOD FOR MANUFACTURING SAME, AND COATING LIQUID USED FOR MANUFACTURING SAME SHOKO CO LTD (JP) 2026-04-08 EP claimed
US-12565625-B2 Thiophosphate esters as antiwear additives for lubricants AFTON CHEMICAL CORPORATION 2026-03-03 US claimed
EP-4683969-A1 COATING COMPOSITIONS AND APPLICATIONS THEREOF Aescula Tech, Inc. (US) 2026-01-28 EP claimed
US-12441897-B2 Polyamidoamine dispersants EVONIK OPERATIONS GMBH (DE) 2025-10-14 US claimed
WO-2025136661-A1 THIOPHOSPHATE ESTERS AS ANTIWEAR ADDITIVES FOR LUBRICANTS AFTON CHEMICAL CORPORATION (US) 2025-06-26 WO claimed
US-20250197756-A1 THIOPHOSPHATE ESTERS AS ANTIWEAR ADDITIVES FOR LUBRICANTS AFTON CHEMICAL CORPORATION 2025-06-19 US claimed
CN-116670235-B Copolymer additives 陶氏环球技术有限责任公司 2025-06-13 CN claimed
WO-2025106369-A1 THICK PARTS AND PROFILES WITH STONE APPEARANCE USING IONOMER RESINS AND BIO-FILLERS DOW QUIMICA MEXICANA S.A.DE C.V. (MX) 2025-05-22 WO claimed
US-4014837-A BIS(HYDROCARBYL)VINYL PHOSPHONATES STAUFFER CHEMICAL COMPANY (US) 1977-03-29 US claimed
US-4013805-A ORGANIC AMINE OR ALKALI METAL BASE AS SOLVENT MONSANTO COMPANY (US) 1977-03-22 US claimed
US-4010222-A CARBOXYLIC ACID COPOLYMERS WHICH ARE AT LEAST TEN PERCENT NEUTRALIZED E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-03-01 US claimed
US-3990980-A Hybrid liquid toners PHILIP A. HUNT CHEMICAL CORPORATION (US) 1976-11-09 US claimed
US-3991226-A Method of creating an image using hybrid liquid toners PHILIP A. HUNT CHEMICAL CORPORATION (US) 1976-11-09 US claimed
US-3976720-A Polyamide/polyolefin plastic graft copolymers E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-08-24 US claimed
US-3963799-A Graft copolymer in polyamide polyethylene blends E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-06-15 US claimed
US-3963801-A CARBOXYLIC ACID COPOLYMERS AND A POLYCARBODIIMIDE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-06-15 US claimed
US-3953408-A LITHOGRAPHIC PLATES ASAHI KASEI KOGYO KABUSHIKI KAISHA (JA) 1976-04-27 US claimed
US-3935140-A ADDITION REACTION PRODUCT OF A NATURAL DRYING OIL, BUTADIENE-PENTADIENE COPOLYMER AND ALPHA,B-UNSATURATED DICARBOXYLIC NIPPON ZEON CO. LTD. (JA) 1976-01-27 US claimed