Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Ethyl Fumarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 9/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.44 |
| ▸ | MDM4 | O15151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethyl Fumarate SCHEMBL30986728 | 1.00 | HCAR2 (1.00) | HCAR2MAPTATMNPSR1CA12 | |
| Ethyl Fumarate SCHEMBL1133862 | 1.00 | HCAR2 (1.00) | HCAR2MAPTATMNPSR1CA12 | |
| Ethyl Fumarate SCHEMBL60568 | 1.00 | HCAR2 (1.00) | HCAR2MAPTATMNPSR1CA12 | |
| Ethyl Fumarate SCHEMBL1133858 | 1.00 | HCAR2 (1.00) | HCAR2MAPTATMNPSR1CA12 | |
| Diethyl Maleate SCHEMBL19873394 | 1.00 | HCAR2 (1.00) | HCAR2MAPTATMNPSR1CA12 | |
| Diethyl Maleate SCHEMBL9193839 | 1.00 | HCAR2 (1.00) | HCAR2MAPTATMNPSR1CA12 | |
| Diethyl Maleate SCHEMBL10994275 | 1.00 | HCAR2 (1.00) | HCAR2MAPTATMNPSR1CA12 | |
| Diethyl Maleate SCHEMBL10994278 | 1.00 | HCAR2 (1.00) | HCAR2MAPTATMNPSR1CA12 | |
| Ethyl Fumarate SCHEMBL60569 | 1.00 | HCAR2 (1.00) | HCAR2MAPTATMNPSR1CA12 | |
| Diethyl Maleate SCHEMBL28937261 | 1.00 | HCAR2 (1.00) | HCAR2MAPTATMNPSR1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3006494-B1 | RESIN COMPOSITION, OPTICAL COMPENSATION FILM EMPLOYING SAME, AND PRODUCTION METHOD FOR SAME | TOSOH CORP (JP) | 2019-07-31 | — | — | EP | disclosed |
| US-9932488-B2 | Resin composition, optical compensation film using same, and production method for same | TOSOH CORPORATION (JP) | 2018-04-03 | — | — | US | disclosed |
| US-20160115333-A1 | RESIN COMPOSITION, OPTICAL COMPENSATION FILM USING SAME, AND PRODUCTION METHOD FOR SAME | TOSOH CORPORATION (JP) | 2016-04-28 | — | — | US | disclosed |
| EP-3006494-A1 | RESIN COMPOSITION, OPTICAL COMPENSATION FILM EMPLOYING SAME, AND PRODUCTION METHOD FOR SAME | Tosoh Corporation (JP) | 2016-04-13 | — | — | EP | disclosed |