Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 18/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2765163 | 1.00 | ADAMTS5 (1.00) | ADAMTS5MAPK1CYP2C19MMP2 | |
| SCHEMBL13398332 | 1.00 | ADAMTS5 (1.00) | ADAMTS5MAPK1CYP2C19MMP2 | |
| SCHEMBL2764668 | 1.00 | ADAMTS5 (1.00) | ADAMTS5MAPK1CYP2C19MMP2 | |
| SCHEMBL2764561 | 1.00 | ADAMTS5 (1.00) | ADAMTS5MAPK1CYP2C19MMP2 | |
| SCHEMBL2764374 | 1.00 | ADAMTS5 (1.00) | ADAMTS5MAPK1CYP2C19MMP2 | |
| SCHEMBL2764182 | 0.92 | ADAMTS5 (0.86) | ADAMTS5MAPK1CYP2C19MMP2 | |
| SCHEMBL2764179 | 0.92 | ADAMTS5 (0.86) | ADAMTS5MAPK1CYP2C19MMP2 | |
| SCHEMBL2765201 | 0.92 | ADAMTS5 (0.85) | ADAMTS5MMP2 | |
| SCHEMBL2765203 | 0.92 | ADAMTS5 (0.85) | ADAMTS5MMP2 | |
| SCHEMBL2765456 | 0.90 | ADAMTS5 (0.82) | ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694410-A2 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | Japan Tobacco, Inc. (JP) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058884-A2 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2005-06-30 | — | — | WO | disclosed |