Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.49 |
| ▸ | STS | P08842 | 1/20 | 0.49 |
| ▸ | YAP1 | P46937 | 3/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7872006 | 0.84 | KDM4E (0.58) | KDM4EPKMSMN1; SMN2GAATHRB | |
| SCHEMBL5574062 | 0.81 | KDM4E (0.51) | KDM4EPKMSMN1; SMN2THRBGPR119 | |
| SCHEMBL8644404 | 0.80 | KDM4E (0.53) | KDM4EPKMSMN1; SMN2GAATHRB | |
| SCHEMBL3170462 | 0.78 | KDM4E (0.54) | KDM4EPKMSMN1; SMN2GPR119STS | |
| SCHEMBL3123967 | 0.78 | GAA (0.60) | KDM4EPKMSMN1; SMN2GAATHRB | |
| SCHEMBL7141623 | 0.78 | KDM4E (0.48) | KDM4EPKMSMN1; SMN2GPR119YAP1 | |
| SCHEMBL3923737 | 0.78 | KDM4E (0.64) | KDM4EPKMGPR119STSLMNA | |
| SCHEMBL5417967 | 0.78 | ATM (0.48) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1912705 | 0.77 | KDM4E (0.62) | KDM4EPKMSMN1; SMN2GAATHRB | |
| SCHEMBL6060188 | 0.77 | CPN1 (0.49) | KDM4EPKMSMN1; SMN2GPR119YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071175-B1 | Pyridine mercapto carboxylic acids as carboxypeptidase U inhibitors | ASTRAZENECA AB (SE) | 2006-07-04 | — | — | US | disclosed |
| EP-1180098-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000066557-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-09 | — | — | WO | disclosed |