Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6059794 | 0.82 | LCK (0.36) | PDPK1USP30MKNK2 | |
| SCHEMBL6058759 | 0.81 | PDPK1 (0.35) | PDPK1USP30MKNK2 | |
| SCHEMBL6059049 | 0.81 | USP30 (0.33) | PDPK1USP30BACE1 | |
| SCHEMBL18359637 | 0.76 | PDPK1 (0.36) | PDPK1USP30MKNK2 | |
| SCHEMBL6058738 | 0.76 | PDPK1 (0.35) | PDPK1USP30BACE1 | |
| SCHEMBL6059056 | 0.75 | PDPK1 (0.34) | PDPK1USP30MKNK2 | |
| SCHEMBL6058840 | 0.74 | USP30 (0.34) | PDPK1USP30MKNK2BACE1 | |
| SCHEMBL31268069 | 0.74 | AAK1 (0.46) | PDPK1USP30MKNK2BACE1 | |
| SCHEMBL30463735 | 0.74 | PDPK1 (0.35) | PDPK1USP30MKNK2 | |
| SCHEMBL30463733 | 0.74 | PDPK1 (0.35) | PDPK1USP30MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071175-B1 | Pyridine mercapto carboxylic acids as carboxypeptidase U inhibitors | ASTRAZENECA AB (SE) | 2006-07-04 | — | — | US | disclosed |
| EP-1180098-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000066557-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-09 | — | — | WO | disclosed |