Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6059048 | 0.82 | SYK (0.37) | PDPK1SYKUSP30 | |
| SCHEMBL6058650 | 0.81 | SYK (0.37) | PDPK1SYKUSP30 | |
| SCHEMBL29874531 | 0.81 | PDPK1 (0.34) | PDPK1BACE1SYK | |
| SCHEMBL26933447 | 0.76 | HDAC1 (0.32) | PDPK1BACE1 | |
| SCHEMBL29875163 | 0.76 | BACE1 (0.33) | PDPK1BACE1 | |
| SCHEMBL6058801 | 0.76 | PDPK1 (0.35) | PDPK1BACE1USP30 | |
| SCHEMBL6059494 | 0.75 | SYK (0.39) | PDPK1SYKUSP30 | |
| SCHEMBL19463410 | 0.74 | BACE1 (0.36) | PDPK1BACE1SYK | |
| SCHEMBL1180650 | 0.74 | SYK (0.36) | PDPK1BACE1SYKUSP30 | |
| SCHEMBL16638904 | 0.74 | SYK (0.36) | PDPK1BACE1SYKUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071175-B1 | Pyridine mercapto carboxylic acids as carboxypeptidase U inhibitors | ASTRAZENECA AB (SE) | 2006-07-04 | — | — | US | disclosed |
| EP-1180098-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000066557-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-09 | — | — | WO | disclosed |