Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EED | O75530 | 1/20 | 0.41 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.41 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.41 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.41 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122218 | 0.85 | GPR119 (0.50) | GPR119DPP4HPGDRECQLEPHX1 | |
| SCHEMBL8495308 | 0.79 | HPGD (0.53) | GPR119DPP4HPGDRECQLEPHX1 | |
| SCHEMBL27446359 | 0.79 | DPP4 (0.52) | GPR119DPP4HPGDRECQLEPHX1 | |
| SCHEMBL3821259 | 0.78 | EPHX1 (0.54) | GPR119DPP4HPGDRECQLEPHX1 | |
| SCHEMBL1873727 | 0.78 | EPHX1 (0.50) | GPR119DPP4HPGDRECQLEPHX1 | |
| SCHEMBL22284409 | 0.78 | GPR119 (0.44) | GPR119HPGDRECQLEPHX1ALDH1A1 | |
| SCHEMBL1422213 | 0.78 | HPGD (0.51) | GPR119DPP4HPGDRECQLEPHX1 | |
| SCHEMBL7493781 | 0.78 | HPGD (0.51) | GPR119DPP4HPGDRECQLEPHX1 | |
| SCHEMBL22284440 | 0.78 | GPR119 (0.42) | GPR119DPP4HPGDRECQLEPHX1 | |
| SCHEMBL22284441 | 0.78 | GPR119 (0.42) | GPR119DPP4HPGDRECQLEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071175-B1 | Pyridine mercapto carboxylic acids as carboxypeptidase U inhibitors | ASTRAZENECA AB (SE) | 2006-07-04 | — | — | US | disclosed |
| EP-1180098-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000066557-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-09 | — | — | WO | disclosed |