Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6059549 | 0.82 | SYK (0.44) | CYP2C9CYP2C19SYKMAPK1KMT2A | |
| SCHEMBL6059213 | 0.82 | CYP2C19 (0.41) | CYP2C9CYP2C19SYKNPC1RAB9A | |
| SCHEMBL23501684 | 0.76 | CYP2C9 (0.49) | CYP2C9CYP2C19NPC1RAB9AMEN1 | |
| SCHEMBL1092469 | 0.75 | CYP2C9 (0.51) | CYP2C9CYP2C19NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16649767 | 0.74 | CYP2C19 (0.40) | CYP2C9CYP2C19SYKNPC1RAB9A | |
| SCHEMBL465766 | 0.74 | SYK (0.47) | CYP2C9CYP2C19SYKNPC1RAB9A | |
| SCHEMBL16421764 | 0.74 | CYP2C9 (0.47) | CYP2C9CYP2C19NPC1RAB9AMAPT | |
| SCHEMBL31405437 | 0.74 | CYP2C9 (0.47) | CYP2C9CYP2C19NPC1RAB9AMEN1 | |
| SCHEMBL4039418 | 0.73 | CYP2C19 (0.57) | CYP2C9CYP2C19SYKNPC1RAB9A | |
| SCHEMBL19266065 | 0.72 | CYP2C9 (0.44) | CYP2C9CYP2C19NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071175-B1 | Pyridine mercapto carboxylic acids as carboxypeptidase U inhibitors | ASTRAZENECA AB (SE) | 2006-07-04 | — | — | US | disclosed |
| EP-1180098-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000066557-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-09 | — | — | WO | disclosed |