Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Budesonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 12/20 | 0.94 |
| ▸ | PGR | P06401 | 7/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.94 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.94 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.94 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.94 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.94 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.94 |
| ▸ | IL5 | P05113 | 1/20 | 0.94 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.94 |
| ▸ | AR | P10275 | 1/20 | 0.94 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.94 |
| ▸ | MMP9 | P14780 | 1/20 | 0.94 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.94 |
| ▸ | THPO | P40225 | 1/20 | 0.94 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.94 |
| ▸ | LMNA | P02545 | 1/20 | 0.94 |
| ▸ | BLM | P54132 | 1/20 | 0.94 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Budesonide SCHEMBL5396843 | 1.00 | NR3C1 (0.94) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Budesonide SCHEMBL4448854 | 0.97 | NR3C1 (0.97) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Budesonide SCHEMBL1786635 | 0.97 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Budesonide SCHEMBL13928654 | 0.97 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Dexbudesonide SCHEMBL4095 | 0.97 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Budesonide SCHEMBL8056801 | 0.97 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Budesonide SCHEMBL14452945 | 0.97 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Budesonide SCHEMBL13695912 | 0.97 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Budesonide SCHEMBL21570019 | 0.97 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Budesonide SCHEMBL13871728 | 0.97 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301173-A1 | A MEDICINAL AEROSOL FORMULATION | Aeropharm Technology Incorporated (US) | 2003-04-16 | — | — | EP | claimed |
| US-6458338-B1 | Amino acid stabilized medicinal aerosol formulations | AEROPHARM TECHNOLOGY INCORPORATED | 2002-10-01 | — | — | US | claimed |
| WO-2002005784-A1 | A MEDICINAL AEROSOL FORMULATION | AEROPHARM TECHNOLOGY, INC. (US) | 2002-01-24 | — | — | WO | claimed |
| CN-115735251-A | System and method for identifying an appropriate patient subgroup for receiving a biological agent | 互惠实验室公司 | 2023-03-03 | — | — | CN | disclosed |
| US-7074388-B2 | Water stabilized medicinal aerosol formulation | KOS LIFE SCIENCE, INC. (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1569617-A1 | WATER STABILIZED MEDICINAL AEROSOL FORMULATION RELATED APPLICATIONS | Kos Life Sciences, Inc. (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004022035-A1 | WATER STABILIZED MEDICINAL AEROSOL FORMULATION RELATED APPLICATIONS | KOS PHARMACEUTICALS, INC. (US) | 2004-03-18 | — | — | WO | disclosed |
| US-20030091512-A1 | Water stabilized medicinal aerosol formulation | KOS LIFE SCIENCES, INC. | 2003-05-15 | — | — | US | disclosed |
| EP-1301173-A1 | A MEDICINAL AEROSOL FORMULATION | Aeropharm Technology Incorporated (US) | 2003-04-16 | — | — | EP | disclosed |
| US-6458338-B1 | Amino acid stabilized medicinal aerosol formulations | AEROPHARM TECHNOLOGY INCORPORATED | 2002-10-01 | — | — | US | disclosed |
| WO-2002015883-A1 | A METHOD OF STABILIZING A DRY POWDER PHARMACEUTICAL FORMULATION | AEROPHARM TECHNOLOGY INCORPORATED (US) | 2002-02-28 | — | — | WO | disclosed |
| WO-2002007672-A2 | A MEDICINAL AEROSOL FORMULATION | AEROPHARM TECHNOLOGY, INC. (US) | 2002-01-31 | — | — | WO | disclosed |
| WO-2002005784-A1 | A MEDICINAL AEROSOL FORMULATION | AEROPHARM TECHNOLOGY, INC. (US) | 2002-01-24 | — | — | WO | disclosed |