Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27653607 | 0.84 | TSHR (0.50) | TSHRL3MBTL1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL2350639 | 0.83 | TSHR (0.42) | TSHRL3MBTL1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL27402471 | 0.77 | TDP1 (0.46) | TSHRTDP1CYP3A4CYP2C9MAPK1 | |
| SCHEMBL27913221 | 0.76 | TSHR (0.53) | TSHRL3MBTL1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL27906657 | 0.76 | TSHR (0.53) | TSHRL3MBTL1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL4503297 | 0.75 | MAPT (0.51) | TSHRL3MBTL1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL6061077 | 0.74 | KDM4E (0.43) | TSHRL3MBTL1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL6061205 | 0.72 | TSHR (0.46) | TSHRL3MBTL1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL522441 | 0.72 | GABRA1 (0.49) | TSHRL3MBTL1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL522362 | 0.71 | EGLN2 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644336-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004108681-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2004-12-16 | — | — | WO | disclosed |