Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.40 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2682152 | 0.98 | SNCA (0.52) | SNCAHTTCYP2C19KDM4EALDH1A1 | |
| Bromide SCHEMBL6060661 | 0.96 | SNCA (0.52) | SNCAHTTCYP2C19KDM4EALDH1A1 | |
| Iodide SCHEMBL6060565 | 0.96 | SNCA (0.48) | SNCAHTTCYP2C19KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL2452316 | 0.92 | SNCA (0.58) | SNCAHTTCYP2C19KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7195007 | 0.89 | SNCA (0.44) | SNCAALDH1A1CYP1A2ACHETAAR1 | |
| Bromide SCHEMBL2447513 | 0.88 | SNCA (0.61) | SNCAHTTCYP2C19ALDH1A1RAB9A | |
| Phosphoric Acid SCHEMBL7195845 | 0.87 | CA12 (0.42) | SNCARAB9ALMNACA12CYP1A2 | |
| Acetic Acid SCHEMBL8750085 | 0.86 | SNCA (0.45) | SNCARAB9APOLBCA12CYP1A2 | |
| Iodide SCHEMBL7197935 | 0.85 | SNCA (0.44) | SNCAALDH1A1RAB9ACYP1A2ACHE | |
| Bromide SCHEMBL7197676 | 0.85 | SNCA (0.47) | SNCAALDH1A1RAB9ACYP1A2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993004122-A1 | POLYESTER COMPOSITIONS CONTAINING PHOSPHONIUM COMPOUNDS | THE DOW CHEMICAL COMPANY (US) | 1993-03-04 | — | — | WO | claimed |
| US-20060229400-A1 | Powder coating matting agent comprising ester amide condensation product | FLETCHER TIM | 2006-10-12 | — | — | US | disclosed |
| US-20050288450-A1 | Coating matting agent comprising amide condensation product | FLETCHER TIM | 2005-12-29 | — | — | US | disclosed |
| EP-1509561-A1 | POWDER COATING MATTING AGENT COMPRISING ESTER AMIDE CONDENSATION PRODUCT | Grace GmbH & Co. KG (DE) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003102048-A1 | POWDER COATING MATTING AGENT COMPRISING ESTER AMIDE CONDENSATION PRODUCT | GRACE GMBH & CO. KG (DE) | 2003-12-11 | — | — | WO | disclosed |
| EP-0624173-B2 | PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS | DOW CHEMICAL CO (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0624173-B1 | PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS | DOW CHEMICAL CO (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0624173-A1 | PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS. | DOW CHEMICAL CO (US) | 1994-11-17 | — | — | EP | disclosed |
| US-5360886-A | Alklyphenylphosphine or phosphonium catalyst | THE DOW CHEMICAL COMPANY (US) | 1994-11-01 | — | — | US | disclosed |
| US-5310853-A | Epoxy resins | THE DOW CHEMICAL COMPANY (US) | 1994-05-10 | — | — | US | disclosed |
| WO-1993015126-A1 | PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS | THE DOW CHEMICAL COMPANY (US) | 1993-08-05 | — | — | WO | disclosed |
| US-5202407-A | Phosphonium or phosphine catalyst having at least three alkylphenyl groups attached to phosphorus atom | THE DOW CHEMICAL COMPANY (US) | 1993-04-13 | — | — | US | disclosed |
| WO-1993004122-A1 | POLYESTER COMPOSITIONS CONTAINING PHOSPHONIUM COMPOUNDS | THE DOW CHEMICAL COMPANY (US) | 1993-03-04 | — | — | WO | disclosed |