Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | VDR | P11473 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5545287 | 0.91 | KDM4E (0.52) | KDM4EL3MBTL1ALDH1A1MAPTPKM | |
| SCHEMBL5545582 | 0.87 | KDM4E (0.41) | KDM4EALDH1A1MAPTPKMLMNA | |
| SCHEMBL6061578 | 0.85 | L3MBTL1 (0.47) | KDM4EL3MBTL1ALDH1A1LMNAHTT | |
| SCHEMBL5545282 | 0.82 | KDM4E (0.55) | KDM4EL3MBTL1ALDH1A1MAPTPKM | |
| SCHEMBL5538837 | 0.82 | KDM4E (0.41) | KDM4EALDH1A1MAPTPKMLMNA | |
| SCHEMBL5545776 | 0.82 | KDM4E (0.41) | KDM4EL3MBTL1ALDH1A1MAPTPKM | |
| SCHEMBL5545311 | 0.81 | KDM4E (0.41) | KDM4EALDH1A1MAPTPKMLMNA | |
| SCHEMBL5541088 | 0.81 | KDM4E (0.47) | KDM4EL3MBTL1ALDH1A1MAPTPKM | |
| SCHEMBL4584171 | 0.81 | GRIN2B (0.41) | KDM4EALDH1A1MAPTPKMLMNA | |
| SCHEMBL5541141 | 0.81 | GAA (0.45) | KDM4EL3MBTL1ALDH1A1MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720856-A2 | HIV INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005077050-A2 | HIV INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-25 | — | — | WO | disclosed |