Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 3/20 | 0.59 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL464764 | 1.00 | SPPL2A (0.59) | SPPL2AADAMTS4MMP2MMP13MMP14 | |
| SCHEMBL4973149 | 0.91 | SPPL2A (0.69) | SPPL2AKEAP1ALDH1A1PSEN1PSEN2 | |
| SCHEMBL4787816 | 0.91 | SPPL2A (0.69) | SPPL2AKEAP1ALDH1A1PSEN1PSEN2 | |
| SCHEMBL4911178 | 0.89 | SPPL2A (0.66) | SPPL2AABCB1ALDH1A1PSEN1PSEN2 | |
| SCHEMBL4345123 | 0.87 | ABCB1 (0.58) | SPPL2AADAMTS4MMP2MMP13MMP14 | |
| SCHEMBL4345120 | 0.87 | ABCB1 (0.58) | SPPL2AADAMTS4MMP2MMP13MMP14 | |
| SCHEMBL4340061 | 0.87 | SPPL2A (0.51) | SPPL2AABCB1ALDH1A1 | |
| SCHEMBL4346699 | 0.87 | SPPL2A (0.50) | SPPL2AABCB1ALDH1A1PSEN1PSEN2 | |
| SCHEMBL1058892 | 0.87 | SPPL2A (0.67) | SPPL2AADAMTS4MMP2MMP13MMP14 | |
| SCHEMBL13617810 | 0.85 | SPPL2A (0.56) | SPPL2AABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194404-B1 | INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMA (US) | 2006-05-03 | — | — | EP | disclosed |