Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.46 |
| ▸ | MLNR | O43193 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4973149 | 1.00 | SPPL2A (0.69) | SPPL2AALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL4911178 | 0.97 | SPPL2A (0.66) | SPPL2AALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL464764 | 0.91 | SPPL2A (0.59) | SPPL2AALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL6061183 | 0.91 | SPPL2A (0.59) | SPPL2AALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL12156755 | 0.87 | SPPL2A (0.67) | SPPL2AALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL5983203 | 0.87 | SPPL2A (0.67) | SPPL2AALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL4906010 | 0.86 | ALDH1A1 (0.53) | SPPL2AALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL4911572 | 0.86 | ALDH1A1 (0.53) | SPPL2AALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL14216612 | 0.86 | SPPL2A (0.55) | SPPL2ALMNAMLNRABCB11CTSD | |
| SCHEMBL4911183 | 0.85 | SPPL2A (0.50) | SPPL2AALDH1A1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222192-B1 | HEXAHYDROFURO¬2,3-B FURAN-3-YL-N- 3-¬(1,3-BENZODIOXOL-5-YLSULFONYL)(ISOBUTYL)AMINO -1-BENZYL-2-HYDROXYPROPYL CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR | TIBOTEC PHARM LTD (IE) | 2008-06-18 | — | — | EP | disclosed |
| US-7157495-B2 | Hexahydrofuro[2,3-B]furan-3-YL-N-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate as retroviral protease inhibitor | TIBOTEC PHARMACEUTICALS, LTD. (IE) | 2007-01-02 | — | — | US | disclosed |
| US-20050261364-A1 | Hexahydrofuro[2,3-b]furan-3-yl-N-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate as retroviral protease inhibitor | JANSSEN SCIENCES IRELAND UC (IE) | 2005-11-24 | — | — | US | disclosed |
| US-6649651-B1 | AIDS; human T-cell lymphoma/leukemia virus or lymphadenopathy associated virus treatment | TIBOTEC PHARMACEUTICALS LTD (IE) | 2003-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261364-A1 | Hexahydrofuro[2,3-b]furan-3-yl-N-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate as retroviral protease inhibitor | HPN, DNPEP, DPEP1 | SPPL2A 1442/4885ALDH1A1 2365/4885PSEN1 561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.