Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | SNCA | P37840 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547499 | 0.86 | TDP1 (0.43) | TDP1EGLN1MEN1KMT2ANPC1 | |
| SCHEMBL27667170 | 0.79 | BTK (0.33) | TDP1MEN1KMT2APKMPARP1 | |
| SCHEMBL6062042 | 0.77 | MEN1 (0.39) | TDP1MEN1KMT2ANPC1PKM | |
| SCHEMBL6061670 | 0.74 | KDM5A (0.39) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL14511037 | 0.74 | TDP1 (0.46) | TDP1MEN1KMT2ANPC1PKM | |
| SCHEMBL15163542 | 0.73 | TDP1 (0.48) | TDP1MEN1KMT2ANPC1PKM | |
| SCHEMBL5540898 | 0.73 | MEN1 (0.46) | EGLN1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL15163541 | 0.72 | TDP1 (0.48) | TDP1MEN1KMT2ANPC1PKM | |
| SCHEMBL5547505 | 0.72 | TDP1 (0.40) | TDP1MEN1KMT2APKMPARP1 | |
| SCHEMBL6061250 | 0.72 | TDP1 (0.33) | TDP1PKMPARP1ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720856-A2 | HIV INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-15 | — | — | EP | claimed |
| WO-2005077050-A2 | HIV INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-25 | — | — | WO | claimed |
| EP-1720856-A2 | HIV INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005077050-A2 | HIV INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-25 | — | — | WO | disclosed |