Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 18/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.55 |
| ▸ | ATF1 | P18846 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380654 | 0.85 | CNR2 (0.64) | CNR2CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL3379898 | 0.82 | CNR2 (0.64) | CNR2CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL5083067 | 0.82 | GAA (0.57) | CNR2CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL6062135 | 0.81 | CNR2 (0.59) | CNR2CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL3381287 | 0.80 | CNR2 (0.49) | CNR2CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL3381215 | 0.78 | CNR2 (0.60) | CNR2CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL3378904 | 0.78 | CNR2 (0.84) | CNR2CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL3383682 | 0.77 | CNR2 (0.75) | CNR2CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL13503332 | 0.77 | CNR2 (0.57) | CNR2CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL13503393 | 0.77 | CNR2 (0.57) | CNR2CYP2C19CYP2C9CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732561-A1 | COMBINATION OF CB2 MODULATORS AND PDE4 INHIBITORS FOR USE IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005074939-A1 | COMBINATION OF CB2 MODULATORS AND PDE4 INHIBITORS FOR USE IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2005-08-18 | — | — | WO | disclosed |