Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 7/20 | 0.51 |
| ▸ | ERCC5 | P28715 | 6/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | PRKACG | P22612 | 1/20 | 0.39 |
| ▸ | PRKACB | P22694 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16999961 | 0.89 | EGLN1 (0.48) | FEN1ERCC5EGLN1MEN1KMT2A | |
| SCHEMBL5545344 | 0.89 | KDM4E (0.46) | FEN1ERCC5EGLN1PTGDR2 | |
| SCHEMBL5545820 | 0.87 | CNR1 (0.49) | FEN1ERCC5EGLN1 | |
| SCHEMBL5538481 | 0.87 | EGLN1 (0.44) | FEN1ERCC5EGLN1PTGDR2MAPK8 | |
| SCHEMBL5545819 | 0.86 | CNR2 (0.52) | FEN1ERCC5EGLN1 | |
| SCHEMBL5546934 | 0.86 | EGLN1 (0.49) | FEN1ERCC5EGLN1MEN1KMT2A | |
| SCHEMBL5545229 | 0.86 | LMNA (0.49) | EGLN1MEN1KMT2A | |
| SCHEMBL5547058 | 0.84 | KDM4E (0.49) | EGLN1MEN1KMT2A | |
| SCHEMBL5538456 | 0.84 | RXFP1 (0.47) | EGLN1MEN1KMT2A | |
| SCHEMBL5545321 | 0.82 | MAPT (0.44) | FEN1ERCC5PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720856-A2 | HIV INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005077050-A2 | HIV INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-25 | — | — | WO | disclosed |