Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 7/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | EIF4E | P06730 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6060884 | 0.92 | NOS1 (0.40) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL4450439 | 0.84 | NOS1 (0.46) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL3758461 | 0.83 | NOS1 (0.43) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL4448719 | 0.83 | NOS1 (0.52) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL3760413 | 0.81 | PIK3CG (0.45) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL6064269 | 0.79 | NOS1 (0.43) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL3760847 | 0.75 | NOS1 (0.44) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL3758359 | 0.75 | NOS1 (0.44) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL3760491 | 0.73 | PIK3CG (0.49) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL3763706 | 0.73 | NOS1 (0.43) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658081-A2 | IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES | 4 AZA Bioscience nv (BE) | 2006-05-24 | — | — | EP | claimed |
| WO-2005021003-A2 | IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES | 4 AZA BIOSCIENCE NV (BE) | 2005-03-10 | — | — | WO | claimed |