SCHEMBL6063008

SCHEMBL6063008

CCC[C@H](NC(=O)[C@H](CS(=O)(=O)Cc1ccccc1)N(C)C1CCNCC1)C(O)c1nc2ccccc2o1

nearest known ligand 0.33

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CTSS P25774 12/20 0.33
CTSL P07711 2/20 0.33
CTSB P07858 2/20 0.33
CTSK P43235 2/20 0.33
PTPN2 P17706 3/20 0.33
PTPN1 P18031 2/20 0.33
FASN P49327 1/20 0.33
ALDH1A1 P00352 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SMYD3 Q9H7B4 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6630474 1.00 CTSS (0.33) CTSSCTSLCTSBCTSKPTPN2
SCHEMBL6632610 0.87 PTPN1 (0.37) CTSSPTPN2PTPN1ALDH1A1CYP3A4
SCHEMBL6062004 0.87 PTPN1 (0.37) CTSSPTPN2PTPN1ALDH1A1CYP3A4
SCHEMBL6062007 0.87 PTPN1 (0.37) CTSSPTPN2PTPN1ALDH1A1CYP3A4
SCHEMBL6062148 0.85 CTSS (0.46) CTSSCTSLCTSBCTSKCYP3A4
SCHEMBL6062606 0.84 PTPN1 (0.37) PTPN2PTPN1ALDH1A1
SCHEMBL6628272 0.84 PTPN1 (0.37) PTPN2PTPN1ALDH1A1
SCHEMBL6632221 0.84 PTPN1 (0.37) PTPN2PTPN1ALDH1A1
SCHEMBL6063015 0.83 PTPN2 (0.33) CTSSCTSLCTSBCTSKPTPN2
SCHEMBL6063021 0.83 PTPN2 (0.33) CTSSCTSLCTSBCTSKPTPN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1397340-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-03-17 EP claimed
WO-2002098850-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-12-12 WO claimed
EP-1694357-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2006-08-30 EP disclosed
WO-2005058348-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2005-06-30 WO disclosed
EP-1397340-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-03-17 EP disclosed
WO-2002098850-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-12-12 WO disclosed