Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | SGK1 | O00141 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4448850 | 0.93 | PIK3CG (0.44) | NOS1ALDH1A1PIK3CGALOX5APFEN1 | |
| SCHEMBL5510798 | 0.91 | NOS1 (0.63) | NOS1ALDH1A1HPGDXDHDYRK1A | |
| SCHEMBL4455139 | 0.83 | PIK3CG (0.42) | NOS1PIK3CGALOX5APFEN1PIK3CA | |
| SCHEMBL3757292 | 0.83 | NOS1 (0.49) | NOS1PIK3CGALOX5APFEN1PIK3CA | |
| SCHEMBL4451388 | 0.82 | NOS1 (0.54) | NOS1ALDH1A1HPGDXDHDYRK1A | |
| SCHEMBL4449231 | 0.81 | NOS1 (0.60) | NOS1PIK3CGPIK3CA | |
| SCHEMBL4451834 | 0.80 | NOS1 (0.51) | NOS1L3MBTL1PIK3CGKDM4EPIK3CA | |
| SCHEMBL4453670 | 0.80 | NOS1 (0.52) | NOS1ALDH1A1PIK3CGKDM4E | |
| SCHEMBL4454718 | 0.79 | PIK3CG (0.45) | NOS1HPGDPIK3CGPIK3CA | |
| SCHEMBL3757239 | 0.79 | NOS1 (0.46) | NOS1ALDH1A1PIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658081-A2 | IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES | 4 AZA Bioscience nv (BE) | 2006-05-24 | — | — | EP | claimed |
| WO-2005021003-A2 | IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES | 4 AZA BIOSCIENCE NV (BE) | 2005-03-10 | — | — | WO | claimed |