Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.63 |
| ▸ | STK17B | O94768 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 3/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5516964 | 0.90 | NOS1 (0.65) | NOS1STK17BMAPK1PIK3CAMAPK8 | |
| SCHEMBL6063982 | 0.85 | NOS1 (0.69) | NOS1DHFRHPGD | |
| SCHEMBL6063923 | 0.84 | NOS1 (0.60) | NOS1STK17BMAPK1PIK3CAMAPK8 | |
| SCHEMBL6062659 | 0.84 | NOS1 (0.60) | NOS1STK17BMAPK1PIK3CAMAPK8 | |
| SCHEMBL6062674 | 0.84 | NOS1 (0.60) | NOS1STK17BMAPK1PIK3CAMAPK8 | |
| SCHEMBL6064072 | 0.84 | NOS1 (0.65) | NOS1MAPK1HPGD | |
| SCHEMBL6063556 | 0.82 | NOS1 (0.55) | NOS1MAPK1DHFRHPGD | |
| SCHEMBL4454283 | 0.81 | NOS1 (0.67) | NOS1MAPK1PIK3CAMAPK8MAPK9 | |
| SCHEMBL6815729 | 0.80 | NOS1 (0.60) | NOS1STK17BBRAFHPGDGAK | |
| SCHEMBL5513759 | 0.79 | NOS1 (0.84) | NOS1PIK3CGGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658081-A2 | IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES | 4 AZA Bioscience nv (BE) | 2006-05-24 | — | — | EP | claimed |
| WO-2005021003-A2 | IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES | 4 AZA BIOSCIENCE NV (BE) | 2005-03-10 | — | — | WO | claimed |