Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 7/20 | 0.60 |
| ▸ | NEK2 | P51955 | 2/20 | 0.45 |
| ▸ | GAK | O14976 | 2/20 | 0.41 |
| ▸ | STK17B | O94768 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5469822 | 0.91 | NOS1 (0.62) | NOS1NEK2GAKSTK17BPDE4D | |
| SCHEMBL5464734 | 0.91 | NOS1 (0.57) | NOS1NEK2GAKSTK17BPDE4D | |
| SCHEMBL6064797 | 0.90 | NOS1 (0.56) | NOS1NEK2GAKSTK17BPDE4D | |
| SCHEMBL5461814 | 0.90 | NOS1 (0.56) | NOS1NEK2GAKSTK17BPDE4D | |
| SCHEMBL5478226 | 0.89 | NOS1 (0.55) | NOS1NEK2GAKSTK17BPDE4D | |
| SCHEMBL5463717 | 0.89 | NOS1 (0.59) | NOS1NEK2GAKSTK17BPDE4D | |
| SCHEMBL5461841 | 0.89 | NOS1 (0.55) | NOS1NEK2GAKSTK17BPDE4D | |
| SCHEMBL5477031 | 0.89 | NOS1 (0.58) | NOS1NEK2GAKSTK17BPDE4D | |
| SCHEMBL5466005 | 0.88 | NOS1 (0.54) | NOS1NEK2GAKSTK17BPDE4D | |
| SCHEMBL5465738 | 0.88 | NOS1 (0.54) | NOS1NEK2GAKSTK17BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673092-A1 | HETEROCYCLE-SUBSTITUTED PTERIDINE DERIVATIVES AND THEIR USE IN THERAPY | 4 AZA Bioscience nv (BE) | 2006-06-28 | — | — | EP | claimed |
| WO-2005039587-A1 | HETEROCYCLE-SUBSTITUTED PTERIDINE DERIVATIVES AND THEIR USE IN THERAPY | 4 AZA BIOSCIENCE NV (BE) | 2005-05-06 | — | — | WO | claimed |